Parasitemia/ParasitemiaUI/GUI.fs

   1 module ParasitemiaUI.GUI
   2
   3 open System
   4 open System.IO
   5 open System.Linq
   6 open System.Windows
   7 open System.Windows.Media
   8 open System.Windows.Controls
   9 open Microsoft.Win32 // For the common dialogs.
  10
  11 open Logger
  12
  13 open ParasitemiaUIControls
  14 open ParasitemiaCore.Config
  15 open ParasitemiaCore.Utils
  16 open Types
  17
  18 let run (defaultConfig : Config) (fileToOpen : string option) =
  19     let app = new Application ()
  20     let win = MainWindow ()
  21
  22     let state = State.State defaultConfig
  23     let mutable currentScale = 1.
  24     let mutable displayHealthy = false
  25     let warningBelowNumberOfRBC = 1000
  26
  27     // Initializations.
  28     let canvasCurrentImageColor = win.canvasCurrentImage.Background
  29     win.menuHightlightRBC.IsChecked <- displayHealthy
  30
  31     // Utils.
  32     let extractRBCPreview (img : Emgu.CV.Image<Emgu.CV.Structure.Bgr, byte>) (rbc : RBC) : Emgu.CV.Image<Emgu.CV.Structure.Bgr, byte> =
  33         let rbcWidth = rbc.size.Width
  34         let rbcHeight = rbc.size.Height
  35         let x = rbc.center.X - rbcWidth / 2. |> roundInt
  36         let y = rbc.center.Y - rbcHeight / 2. |> roundInt
  37         let w = roundInt rbcWidth
  38         let h = roundInt rbcHeight
  39         img.GetSubRect (
  40             System.Drawing.Rectangle (
  41                 System.Drawing.Point ((if x < 0 then 0 else x), (if y < 0 then 0 else y)),
  42                 System.Drawing.Size ((if x + w >= img.Width then img.Width - x else w), (if y + h >= img.Height then img.Height - y else h))
  43             )
  44         )
  45
  46     let setRBCFrameStyle (srcImg : SourceImage) (rbc : RBC) (frame : RBCFrame) =
  47         frame.Opacity <- if displayHealthy || rbc.setManually || rbc.infected then 1. else 0.
  48         let color = if rbc.infected then srcImg.InfectedRBCColor else srcImg.HealthyRBCColor
  49         frame.manuallyAdded.Visibility <- if rbc.setManually then Visibility.Visible else Visibility.Hidden
  50         frame.manuallyAdded.Fill <- color
  51         frame.border.Stroke <- color
  52
  53     let frameStrokeThickness (averageRBCSize : float) =
  54         max 1. (averageRBCSize / 60.)
  55
  56     let frameFontSize (averageRBCSize : float) =
  57         max 1. (averageRBCSize / 8.)
  58
  59     let createRBCFrameFromExisting (srcImg : SourceImage) (rbc : RBC) (frame : RBCFrame) (frameThickness : float) (fontSize : float) : RBCFrame =
  60         frame.Visibility <- Visibility.Visible
  61         frame.Width <- rbc.size.Width
  62         frame.Height <- rbc.size.Height
  63         frame.Tag <- rbc
  64         setRBCFrameStyle srcImg rbc frame
  65         frame.border.StrokeThickness <- frameThickness
  66         frame.txtRBCNumber.Text <- string rbc.num
  67         frame.txtRBCNumber.FontSize <- fontSize
  68         frame
  69
  70     let updateDocumentStatus () =
  71         win.txtDocumentStatus.Text <- if state.FilePath = "" then "<New document>" else state.FilePath
  72
  73     let statusMessageTimer = Threading.DispatcherTimer ()
  74     statusMessageTimer.Tick.AddHandler (fun obj args -> statusMessageTimer.Stop (); win.txtMessageStatus.Text <- "")
  75     statusMessageTimer.Interval <- TimeSpan (0, 0, 2)
  76
  77     // To show a use message while a short period of time.
  78     let displayStatusMessage (message : string) =
  79         win.txtMessageStatus.Text <- message
  80         statusMessageTimer.Stop ()
  81         statusMessageTimer.Start ()
  82
  83     let highlightRBCFrame (frame : RBCFrame) (highlight : bool) =
  84         let rbc = frame.Tag :?> RBC
  85         if highlight then
  86             frame.border.StrokeThickness <- 3. * frame.border.StrokeThickness
  87             if not rbc.infected && not rbc.setManually && not displayHealthy then frame.Opacity <- 1.
  88         else
  89             frame.border.StrokeThickness <- frame.border.StrokeThickness / 3.
  90             if not rbc.infected && not rbc.setManually && not displayHealthy then frame.Opacity <- 0.
  91
  92     let zoomToRBC (rbc : RBC) =
  93         win.scrollViewCurrentImage.ScrollToHorizontalOffset (rbc.center.X * currentScale - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
  94         win.scrollViewCurrentImage.ScrollToVerticalOffset (rbc.center.Y * currentScale - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
  95
  96     let txtImageName_TextChanged =
  97         TextChangedEventHandler (fun obj args -> state.CurrentImage |> Option.iter (fun srcImg -> state.SetName srcImg win.txtImageName.Text))
  98
  99     let updateCurrentImageInformation () =
 100         win.txtImageName.TextChanged.RemoveHandler (txtImageName_TextChanged)
 101         win.txtImageInformation1.Inlines.Clear ()
 102         win.txtImageInformation2.Inlines.Clear ()
 103         win.txtImageName.Text <- ""
 104
 105         match state.CurrentImage with
 106         | Some srcImg ->
 107             win.gridImageInformation.Visibility <- Visibility.Visible
 108             win.txtImageName.Text <- srcImg.Name
 109             win.txtImageName.TextChanged.AddHandler txtImageName_TextChanged
 110
 111             // The left part.
 112             let parasitemiaStr = Utils.percentText srcImg.ImageParasitemia
 113             win.txtImageInformation1.Inlines.Add (Documents.Run ("Parasitemia: ", FontWeight = FontWeights.Bold))
 114             win.txtImageInformation1.Inlines.Add parasitemiaStr
 115             win.txtImageInformation1.Inlines.Add (Documents.LineBreak ())
 116
 117             win.txtImageInformation1.Inlines.Add (Documents.Run ("Last analysis: ", FontWeight = FontWeights.Bold))
 118             win.txtImageInformation1.Inlines.Add (Documents.Run (if srcImg.DateLastAnalysis.Ticks = 0L then "<Never>" else string (srcImg.DateLastAnalysis.ToLocalTime())))
 119
 120             // The right part part.
 121             win.txtImageInformation2.Inlines.Add (Documents.Run ("Added infected erythrocyte: ", FontWeight = FontWeights.Bold))
 122             win.txtImageInformation2.Inlines.Add (Documents.Run ((srcImg.ImageNbManuallyChangedRBCStr true) + " " + (srcImg.ImageManuallyChangedRBCStr true)))
 123             win.txtImageInformation2.Inlines.Add (Documents.LineBreak ())
 124             win.txtImageInformation2.Inlines.Add (Documents.Run ("Removed infected erythrocyte: ", FontWeight = FontWeights.Bold))
 125             win.txtImageInformation2.Inlines.Add (Documents.Run ((srcImg.ImageNbManuallyChangedRBCStr false) + " " + (srcImg.ImageManuallyChangedRBCStr false)))
 126
 127         | _ ->
 128             win.gridImageInformation.Visibility <- Visibility.Hidden
 129
 130     let updateGlobalParasitemia () =
 131         win.txtGlobalParasitemia.Inlines.Clear ()
 132         let total, infected = state.GlobalParasitemia
 133         win.txtGlobalParasitemia.Inlines.Add (Documents.Run (Utils.percentText (total, infected), FontWeight = FontWeights.Bold))
 134         if total > 0 && total < warningBelowNumberOfRBC then
 135             win.txtGlobalParasitemia.Inlines.Add (
 136                 Documents.Run (
 137                     sprintf " Warning: the number of erythrocytes should be above %d" warningBelowNumberOfRBC,
 138                     FontWeight = FontWeights.Bold,
 139                     Foreground = Brushes.Red
 140                 )
 141             )
 142
 143     let updateViewportPreview () =
 144         for preview in win.stackPreviews.Children |> Seq.cast<ImageSourcePreview> do
 145             let srcImg = preview.Tag :?> SourceImage
 146             if Some srcImg = state.CurrentImage then
 147                 preview.viewport.Visibility <- Visibility.Visible
 148
 149                 let canvasWidth = win.canvasCurrentImage.ActualWidth * currentScale
 150                 let canvasHeight = win.canvasCurrentImage.ActualHeight * currentScale
 151                 let previewWidth = (preview.ActualWidth - preview.BorderThickness.Left - preview.BorderThickness.Right)
 152                 let previewHeight = (preview.ActualHeight - preview.BorderThickness.Top - preview.BorderThickness.Bottom)
 153
 154                 let marginLeft = previewWidth * (win.scrollViewCurrentImage.HorizontalOffset - win.borderCurrentImage.BorderThickness.Left) / canvasWidth - 2.
 155                 let marginRight = previewWidth * (canvasWidth - (win.scrollViewCurrentImage.HorizontalOffset - win.borderCurrentImage.BorderThickness.Right) - win.scrollViewCurrentImage.ViewportWidth) / canvasWidth - 2.
 156                 let marginTop = previewHeight * (win.scrollViewCurrentImage.VerticalOffset - win.borderCurrentImage.BorderThickness.Top) / canvasHeight - 2.
 157                 let marginBottom = previewHeight * (canvasHeight - (win.scrollViewCurrentImage.VerticalOffset - win.borderCurrentImage.BorderThickness.Bottom) - win.scrollViewCurrentImage.ViewportHeight) / canvasHeight - 2.
 158
 159                 preview.viewport.Margin <-
 160                     Thickness (
 161                         marginLeft,
 162                         marginTop,
 163                         marginRight,
 164                         marginBottom
 165                     )
 166             else
 167                 preview.viewport.Visibility <- Visibility.Hidden
 168
 169     let rec setAsInfected (srcImg : SourceImage) (rbc : RBC) (infected : bool) =
 170         state.SetAsInfected rbc infected
 171         win.canvasCurrentImage.Children
 172         |> Seq.cast<RBCFrame>
 173         |> Seq.iter (
 174             fun frame ->
 175                 if (frame.Tag :?> RBC) = rbc then
 176                     setRBCFrameStyle srcImg rbc frame
 177         )
 178         updateRBCFramesPreview ()
 179         updateCurrentImageInformation ()
 180         updateGlobalParasitemia ()
 181
 182     and createRBCFrame (srcImg : SourceImage) (rbc : RBC) (frameThickness : float) (fontSize : float) : RBCFrame =
 183         let frame = createRBCFrameFromExisting srcImg rbc (RBCFrame ()) frameThickness fontSize
 184         frame.SetValue (Panel.ZIndexProperty, Int32.MaxValue - rbc.num) // To be sure the
 185         frame.menuRBCSetAsHealthy.Click.AddHandler (fun obj args -> setAsInfected srcImg (frame.Tag :?> RBC) false)
 186         frame.menuRBCSetAsInfected.Click.AddHandler (fun obj args -> setAsInfected srcImg (frame.Tag :?> RBC) true)
 187         frame.ContextMenuOpening.AddHandler (
 188             fun obj args ->
 189                 if (frame.Tag :?> RBC).infected then
 190                     frame.menuRBCSetAsHealthy.Visibility <- Visibility.Visible
 191                     frame.menuRBCSetAsInfected.Visibility <- Visibility.Collapsed
 192                 else
 193                     frame.menuRBCSetAsHealthy.Visibility <- Visibility.Collapsed
 194                     frame.menuRBCSetAsInfected.Visibility <- Visibility.Visible
 195         )
 196         frame.ContextMenuClosing.AddHandler (fun obj args -> if not frame.IsMouseOver then highlightRBCFrame frame false )
 197         frame.MouseEnter.AddHandler (fun obj args -> highlightRBCFrame frame true)
 198         frame.MouseLeave.AddHandler (fun obj args -> if not frame.grid.ContextMenu.IsOpen then highlightRBCFrame frame false)
 199         frame
 200
 201     and updateRBCFramesPreview () =
 202         match state.CurrentImage with
 203         | Some srcImg ->
 204             let mutable currentPreview = 0
 205             for rbc in srcImg.RBCs |> List.filter (fun rbc -> displayHealthy || rbc.infected) do
 206                 let previewInfected =
 207                     if currentPreview < win.stackRBC.Children.Count then
 208                         createRBCFrameFromExisting srcImg rbc (win.stackRBC.Children.[currentPreview] :?> RBCFrame) 1. 12.
 209                     else
 210                         let f = createRBCFrame srcImg rbc 1. 12.
 211                         f.MouseLeftButtonUp.AddHandler (fun obj args -> zoomToRBC (f.Tag :?> RBC))
 212                         win.stackRBC.Children.Add f |> ignore
 213                         f
 214
 215                 currentPreview <- currentPreview + 1
 216
 217                 previewInfected.Height <- win.stackRBC.ActualHeight
 218                 previewInfected.Width <- win.stackRBC.ActualHeight * rbc.size.Width / rbc.size.Height
 219                 previewInfected.border.Fill <- ImageBrush (BitmapSourceConvert.ToBitmapSource (extractRBCPreview srcImg.Img rbc))
 220
 221             win.stackRBC.Children.RemoveRange (currentPreview, win.stackRBC.Children.Count - currentPreview)
 222         | _ -> ()
 223
 224         updateViewportPreview ()
 225
 226     let updateRBCFramesCurrent () =
 227         match state.CurrentImage with
 228         | Some srcImg ->
 229             let mutable currentCanvas = 0
 230             let strokeThickness = frameStrokeThickness srcImg.AverageRBCSize
 231             let fontSize = frameFontSize srcImg.AverageRBCSize
 232             for rbc in srcImg.RBCs do
 233                 let frame =
 234                     if currentCanvas < win.canvasCurrentImage.Children.Count then
 235                         createRBCFrameFromExisting srcImg rbc (win.canvasCurrentImage.Children.[currentCanvas] :?> RBCFrame) strokeThickness fontSize
 236                     else
 237                         let f = createRBCFrame srcImg rbc strokeThickness fontSize
 238                         win.canvasCurrentImage.Children.Add f |> ignore
 239                         f
 240
 241                 currentCanvas <- currentCanvas + 1
 242
 243                 Canvas.SetLeft (frame, rbc.center.X - rbc.size.Width / 2.)
 244                 Canvas.SetTop (frame, rbc.center.Y - rbc.size.Height / 2.)
 245
 246             for i in currentCanvas .. win.canvasCurrentImage.Children.Count - 1 do
 247                 win.canvasCurrentImage.Children.[i].Visibility <- Visibility.Hidden
 248         | _ -> ()
 249
 250     let askDocumentPathToSave () : string option =
 251         let dialog = SaveFileDialog (AddExtension = true, DefaultExt = PiaZ.extension, Filter = PiaZ.filter)
 252
 253         if state.FilePath <> "" then
 254             dialog.FileName <- FileInfo(state.FilePath).Name
 255         elif state.PatientID <> "" then
 256             dialog.FileName <- state.PatientID + PiaZ.extension
 257
 258         let res = dialog.ShowDialog ()
 259         if res.HasValue && res.Value then
 260             Some dialog.FileName
 261         else
 262             None
 263
 264     let saveCurrentDocument () =
 265         try
 266             if state.FilePath = "" then
 267                 match askDocumentPathToSave () with
 268                 | Some filepath ->
 269                     state.FilePath <- filepath
 270                     state.Save ()
 271                 | _ -> ()
 272             else
 273                 state.Save ()
 274             updateDocumentStatus ()
 275             displayStatusMessage "Document saved"
 276         with
 277         | :? IOException as ex ->
 278             Log.Error "%O" ex
 279             MessageBox.Show (sprintf "The document cannot be save in \"%s\"" state.FilePath, "Error saving the document", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 280
 281     let saveCurrentDocumentAsNewFile () =
 282         match askDocumentPathToSave () with
 283         | Some filepath ->
 284             state.FilePath <- filepath
 285             saveCurrentDocument ()
 286         | _ -> ()
 287
 288     // Ask the use to save the current document if neccessary.
 289     let askSaveCurrent () =
 290         if state.AlteredSinceLastSave then
 291             match MessageBox.Show ("Would you like to save the current document?", "Saving the current document", MessageBoxButton.YesNo, MessageBoxImage.Question) with
 292             | MessageBoxResult.Yes -> saveCurrentDocument ()
 293             | _ -> ()
 294
 295     let updateCurrentImage () =
 296         match state.CurrentImage with
 297         | Some srcImg ->
 298             win.imgLogos.Visibility <- Visibility.Collapsed
 299
 300             // Highlight the preview.
 301             win.stackPreviews.Children
 302             |> Seq.cast<ImageSourcePreview>
 303             |> Seq.iter (fun preview -> preview.border.BorderThickness <- Thickness (if preview.Tag = (srcImg :> Object) then 3. else 0.))
 304
 305             win.canvasCurrentImage.Height <- float srcImg.Img.Height
 306             win.canvasCurrentImage.Width <- float srcImg.Img.Width
 307             win.canvasCurrentImage.Background <- ImageBrush (BitmapSourceConvert.ToBitmapSource (srcImg.Img))
 308
 309             updateRBCFramesCurrent ()
 310             updateRBCFramesPreview ()
 311
 312         | None ->
 313             win.imgLogos.Visibility <- Visibility.Visible
 314
 315             win.stackRBC.Children.Clear ()
 316             win.canvasCurrentImage.Children.Clear ()
 317             win.canvasCurrentImage.Background <- canvasCurrentImageColor
 318
 319         updateCurrentImageInformation ()
 320
 321     let setCurrentImage (srcImg : SourceImage) =
 322         if state.CurrentImage.IsNone || state.CurrentImage.Value <> srcImg then
 323             state.CurrentImage <- Some srcImg
 324             updateCurrentImage ()
 325
 326     let addPreview (srcImg : SourceImage) =
 327         let imgCtrl = ImageSourcePreview (Margin = Thickness 3.)
 328
 329         imgCtrl.menuRemoveImage.Click.AddHandler (
 330             fun obj args ->
 331                 win.stackPreviews.Children.Remove (imgCtrl)
 332                 let srcImg = imgCtrl.Tag :?> SourceImage
 333                 let currentRemoved = Some srcImg = state.CurrentImage
 334                 state.RemoveSourceImage srcImg
 335                 if currentRemoved then
 336                     updateCurrentImage ()
 337
 338                 updateGlobalParasitemia ()
 339
 340                 // Update image numbers.
 341                 win.stackPreviews.Children |> Seq.cast<ImageSourcePreview> |> Seq.iter (fun imgPreview -> imgPreview.txtImageNumber.Text <- (imgPreview.Tag :?> SourceImage).RomanNum)
 342         )
 343
 344         imgCtrl.Tag <- srcImg
 345         imgCtrl.txtImageNumber.Text <- string srcImg.RomanNum
 346         let width = 200
 347         let height = srcImg.Img.Height * width / srcImg.Img.Width
 348         imgCtrl.imagePreview.Source <- BitmapSourceConvert.ToBitmapSource (srcImg.Img.Resize (width, height, Emgu.CV.CvEnum.Inter.Cubic))
 349         win.stackPreviews.Children.Add imgCtrl |> ignore
 350
 351         // Zoom to a mouse position into the control 'imgCtrl'.
 352         let zoomTo (mousePos : Point) =
 353             let canvasW = win.canvasCurrentImage.ActualWidth * currentScale
 354             let canvasH = win.canvasCurrentImage.ActualHeight * currentScale
 355             let centerX = (mousePos.X - imgCtrl.BorderThickness.Left) / (imgCtrl.ActualWidth - imgCtrl.BorderThickness.Left) * canvasW
 356             let centerY = (mousePos.Y - imgCtrl.BorderThickness.Top) / (imgCtrl.ActualHeight - imgCtrl.BorderThickness.Top) * canvasH
 357             win.scrollViewCurrentImage.ScrollToHorizontalOffset (centerX - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
 358             win.scrollViewCurrentImage.ScrollToVerticalOffset (centerY - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
 359
 360         imgCtrl.MouseLeftButtonDown.AddHandler (
 361             fun obj args ->
 362                 setCurrentImage (state.SourceImages |> Seq.find (fun srcImg -> (srcImg :> Object) = imgCtrl.Tag))
 363                 imgCtrl.UpdateLayout ()
 364                 zoomTo (args.GetPosition (imgCtrl))
 365                 imgCtrl.CaptureMouse () |> ignore
 366         )
 367
 368         imgCtrl.MouseMove.AddHandler (
 369             fun obj args ->
 370                 if imgCtrl.IsMouseCaptured then
 371                     zoomTo (args.GetPosition imgCtrl)
 372         )
 373
 374         imgCtrl.MouseLeftButtonUp.AddHandler (
 375             fun obj args ->
 376                 if imgCtrl.IsMouseCaptured then
 377                     imgCtrl.ReleaseMouseCapture ()
 378         )
 379
 380     let updatePreviews () =
 381         win.stackPreviews.Children.Clear ()
 382         for srcImg in state.SourceImages do
 383             addPreview srcImg
 384         updateCurrentImage ()
 385
 386     let updateGUI () =
 387         win.txtPatient.Text <- state.PatientID
 388         updatePreviews ()
 389         updateGlobalParasitemia ()
 390         updateDocumentStatus ()
 391
 392     let loadFile (filepath : string) =
 393         askSaveCurrent ()
 394         let previousFilePath = state.FilePath
 395         try
 396             state.FilePath <- filepath
 397             state.Load ()
 398             updateGUI ()
 399         with
 400         | :? IOException as ex ->
 401             Log.Error "%O" ex
 402             state.FilePath <- previousFilePath
 403             MessageBox.Show (sprintf "The document cannot be loaded from \"%s\"" filepath, "Error loading the document", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 404
 405     let askLoadFile () =
 406         let dialog = OpenFileDialog (Filter = PiaZ.filter)
 407         let res = dialog.ShowDialog ()
 408         if res.HasValue && res.Value then
 409             loadFile dialog.FileName
 410
 411     let newFile () =
 412         askSaveCurrent ()
 413         state.Reset ()
 414         updateGUI ()
 415
 416     let exportResults () =
 417         let extension = ".txt"
 418         let dialog = SaveFileDialog (AddExtension = true, DefaultExt = extension)
 419
 420         if state.FilePath <> "" then
 421             dialog.FileName <- Path.GetFileNameWithoutExtension state.FilePath + extension
 422         elif state.PatientID <> "" then
 423             dialog.FileName <- state.PatientID + extension
 424
 425         let res = dialog.ShowDialog ()
 426         if res.HasValue && res.Value then
 427             try
 428                 Export.exportResults state dialog.FileName
 429             with
 430             | :? IOException as ex ->
 431                 Log.Error "%O" ex
 432                 MessageBox.Show (sprintf "The results cannot be exported in \"%s\"" state.FilePath, "Error exporting the files", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 433
 434     let importImage () =
 435         let dialog = OpenFileDialog (Filter = "Image Files|*.png;*.jpg;*.tif;*.tiff", Multiselect = true)
 436         let res = dialog.ShowDialog ()
 437         if res.HasValue && res.Value then
 438             let noSourceImage = state.SourceImages.Count () = 0
 439
 440             for filename in dialog.FileNames do
 441                 try
 442                     let srcImg = state.AddSourceImage filename defaultConfig
 443                     addPreview srcImg
 444                 with
 445                 | _ as ex ->
 446                     Log.Error "%O" ex
 447                     MessageBox.Show (sprintf "Unable to read the image from \"%s\"" filename, "Error adding an image", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 448
 449             updateGlobalParasitemia ()
 450
 451             if noSourceImage then
 452                 updateCurrentImage ()
 453
 454     let showAnalysisWindow () =
 455         if Analysis.showWindow win state then
 456             updateGlobalParasitemia ()
 457             updateCurrentImage ()
 458
 459     let setHighlightRBC (highlight : bool) =
 460         displayHealthy <- highlight
 461         updateRBCFramesPreview ()
 462         updateRBCFramesCurrent ()
 463
 464     win.txtPatient.TextChanged.AddHandler (fun obj args -> state.PatientID <- win.txtPatient.Text)
 465
 466     win.menuExit.Click.AddHandler (fun obj args -> win.Close ())
 467     win.menuSave.Click.AddHandler (fun obj args -> saveCurrentDocument ())
 468     win.menuSaveAs.Click.AddHandler (fun obj args -> saveCurrentDocumentAsNewFile ())
 469     win.menuOpen.Click.AddHandler (fun obj args -> askLoadFile ())
 470     win.menuNew.Click.AddHandler (fun obj args -> newFile ())
 471     win.menuExportResults.Click.AddHandler (fun obj args -> exportResults ())
 472
 473     win.menuAddSourceImage.Click.AddHandler (fun obj args -> importImage ())
 474
 475     win.menuAnalysis.SubmenuOpened.AddHandler (fun obj args -> win.menuStartAnalysis.IsEnabled <- state.SourceImages.Count () > 0)
 476
 477     win.menuStartAnalysis.Click.AddHandler (fun obj args -> showAnalysisWindow ())
 478
 479     win.menuHightlightRBC.Click.AddHandler (fun obj args -> setHighlightRBC win.menuHightlightRBC.IsChecked)
 480
 481     win.menuAbout.Click.AddHandler (fun obj args -> About.showWindow win)
 482
 483     win.menuCommandLineArguments.Click.AddHandler (fun obj args -> CommandLineArguments.showWindow win)
 484
 485     win.Closing.AddHandler (fun obj args -> askSaveCurrent ())
 486
 487     // Zoom on the current image.
 488     let adjustCurrentImageBorders (deltaX : float) (deltaY : float) =
 489         win.borderCurrentImage.BorderThickness <-
 490             Thickness (
 491                 (win.scrollViewCurrentImage.ViewportWidth + deltaX) / 2.,
 492                 (win.scrollViewCurrentImage.ViewportHeight + deltaY) / 2.,
 493                 (win.scrollViewCurrentImage.ViewportWidth + deltaX) / 2.,
 494                 (win.scrollViewCurrentImage.ViewportHeight + deltaY) / 2.
 495             )
 496
 497     win.canvasCurrentImage.SizeChanged.AddHandler (
 498         fun obj args ->
 499             let deltaX = args.NewSize.Width - args.PreviousSize.Width
 500             let deltaY = args.NewSize.Height - args.PreviousSize.Height
 501             if deltaX > 0.5 || deltaY > 0.5 then
 502                 adjustCurrentImageBorders 0.0 0.0
 503                 // Center the view at the center of the image initialy.
 504                 win.scrollViewCurrentImage.UpdateLayout ()
 505                 win.scrollViewCurrentImage.ScrollToHorizontalOffset (win.borderCurrentImage.ActualWidth / 2. - win.scrollViewCurrentImage.ViewportWidth / 2.)
 506                 win.scrollViewCurrentImage.ScrollToVerticalOffset (win.borderCurrentImage.ActualHeight / 2. - win.scrollViewCurrentImage.ViewportHeight / 2.)
 507     )
 508
 509     win.scrollViewCurrentImage.SizeChanged.AddHandler (
 510         fun obj args ->
 511             let deltaX = args.NewSize.Width - args.PreviousSize.Width
 512             let deltaY = args.NewSize.Height - args.PreviousSize.Height
 513             adjustCurrentImageBorders deltaX deltaY
 514             win.scrollViewCurrentImage.ScrollToHorizontalOffset (win.scrollViewCurrentImage.HorizontalOffset + deltaX / 8.)
 515             win.scrollViewCurrentImage.ScrollToVerticalOffset (win.scrollViewCurrentImage.VerticalOffset + deltaY / 8.)
 516     )
 517
 518     let mutable maxScale = 4.
 519     let mutable minScale = 0.25
 520     let currentImageScaleTransform = ScaleTransform ()
 521     win.canvasCurrentImage.LayoutTransform <- currentImageScaleTransform
 522     win.borderCurrentImage.PreviewMouseWheel.AddHandler (
 523         fun _obj args ->
 524             let scaleFactor = if args.Delta > 0 then 2.0 else 0.5
 525             if scaleFactor > 1. && currentScale < maxScale || scaleFactor < 1. && currentScale > minScale then
 526                 let previousScale = currentScale
 527                 currentScale <-
 528                     let newScale = currentScale * scaleFactor
 529                     if newScale > maxScale then maxScale elif newScale < minScale then minScale else newScale
 530                 let realScaleFactor = currentScale / previousScale
 531
 532                 let centerX = win.scrollViewCurrentImage.HorizontalOffset + win.scrollViewCurrentImage.ViewportWidth / 2. - win.borderCurrentImage.BorderThickness.Left
 533                 let centerY = win.scrollViewCurrentImage.VerticalOffset + win.scrollViewCurrentImage.ViewportHeight / 2. - win.borderCurrentImage.BorderThickness.Top
 534
 535                 currentImageScaleTransform.ScaleX <- currentScale
 536                 currentImageScaleTransform.ScaleY <- currentScale
 537
 538                 win.scrollViewCurrentImage.ScrollToHorizontalOffset (centerX * realScaleFactor - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
 539                 win.scrollViewCurrentImage.ScrollToVerticalOffset (centerY * realScaleFactor - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
 540
 541             args.Handled <- true
 542     )
 543
 544     // Pan on the current image.
 545     let mutable scrollStartPosition = Point (0., 0.)
 546     let mutable scrollStartOffsetX = 0.
 547     let mutable scrollStartOffsetY = 0.
 548     win.borderCurrentImage.PreviewMouseLeftButtonDown.AddHandler (
 549         fun _obj args ->
 550             scrollStartPosition <- args.GetPosition win.scrollViewCurrentImage
 551             scrollStartOffsetX <- win.scrollViewCurrentImage.HorizontalOffset
 552             scrollStartOffsetY <- win.scrollViewCurrentImage.VerticalOffset
 553             win.borderCurrentImage.Cursor <- Input.Cursors.ScrollAll
 554             win.borderCurrentImage.CaptureMouse () |> ignore
 555             args.Handled <- true
 556     )
 557
 558     win.borderCurrentImage.PreviewMouseMove.AddHandler (
 559         fun _obj args ->
 560             if win.borderCurrentImage.IsMouseCaptured then
 561                 let position = args.GetPosition win.scrollViewCurrentImage
 562                 let deltaX = scrollStartPosition.X - position.X
 563                 let deltaY = scrollStartPosition.Y - position.Y
 564                 win.scrollViewCurrentImage.ScrollToHorizontalOffset (deltaX + scrollStartOffsetX)
 565                 win.scrollViewCurrentImage.ScrollToVerticalOffset (deltaY + scrollStartOffsetY)
 566
 567                 args.Handled <- true
 568     )
 569
 570     win.borderCurrentImage.PreviewMouseLeftButtonUp.AddHandler (
 571         fun _obj args ->
 572             if win.borderCurrentImage.IsMouseCaptured then
 573                 win.borderCurrentImage.Cursor <- Input.Cursors.Arrow
 574                 win.borderCurrentImage.ReleaseMouseCapture ()
 575                 args.Handled <- true
 576     )
 577
 578     // Shortcuts.
 579     // Save.
 580     win.InputBindings.Add (
 581         Input.KeyBinding (
 582             ViewModule.FunCommand ((fun obj -> saveCurrentDocument ()), (fun obj -> true)),
 583             Input.KeyGesture (Input.Key.S, Input.ModifierKeys.Control)
 584         )
 585     ) |> ignore
 586
 587     // Save as.
 588     win.InputBindings.Add (
 589         Input.KeyBinding (
 590             ViewModule.FunCommand ((fun obj -> saveCurrentDocumentAsNewFile ()), (fun obj -> true)),
 591             Input.KeyGesture (Input.Key.S, Input.ModifierKeys.Control ||| Input.ModifierKeys.Shift)
 592         )
 593     ) |> ignore
 594
 595     // Open.
 596     win.InputBindings.Add (
 597         Input.KeyBinding (
 598             ViewModule.FunCommand ((fun obj -> askLoadFile ()), (fun obj -> true)),
 599             Input.KeyGesture (Input.Key.O, Input.ModifierKeys.Control)
 600         )
 601     ) |> ignore
 602
 603     // New file.
 604     win.InputBindings.Add (
 605         Input.KeyBinding (
 606             ViewModule.FunCommand ((fun obj -> newFile ()), (fun obj -> true)),
 607             Input.KeyGesture (Input.Key.N, Input.ModifierKeys.Control)
 608         )
 609     ) |> ignore
 610
 611     // Export results.
 612     win.InputBindings.Add (
 613         Input.KeyBinding (
 614             ViewModule.FunCommand ((fun obj -> exportResults ()), (fun obj -> true)),
 615             Input.KeyGesture (Input.Key.E, Input.ModifierKeys.Control)
 616         )
 617     ) |> ignore
 618
 619     // Import an image.
 620     win.InputBindings.Add (
 621         Input.KeyBinding (
 622             ViewModule.FunCommand ((fun obj -> importImage ()), (fun obj -> true)),
 623             Input.KeyGesture (Input.Key.A, Input.ModifierKeys.Control)
 624         )
 625     ) |> ignore
 626
 627     // Show analysis dialog.
 628     win.InputBindings.Add (
 629         Input.KeyBinding (
 630             ViewModule.FunCommand ((fun obj -> showAnalysisWindow ()), (fun obj -> state.SourceImages.Count () > 0)),
 631             Input.KeyGesture (Input.Key.Y, Input.ModifierKeys.Control)
 632         )
 633     ) |> ignore
 634
 635     // Toggle RBC highlight.
 636     win.InputBindings.Add (
 637         Input.KeyBinding (
 638             ViewModule.FunCommand (
 639                 (
 640                     fun obj ->
 641                         win.menuHightlightRBC.IsChecked <- not win.menuHightlightRBC.IsChecked
 642                         setHighlightRBC win.menuHightlightRBC.IsChecked
 643                 ),
 644                 (fun obj -> true)
 645             ),
 646             Input.KeyGesture (Input.Key.H, Input.ModifierKeys.Control)
 647         )
 648     ) |> ignore
 649
 650     // Viewport preview.
 651     win.scrollViewCurrentImage.ScrollChanged.AddHandler (fun obj args -> updateViewportPreview ())
 652
 653     updateDocumentStatus ()
 654     win.gridImageInformation.Visibility <- Visibility.Hidden
 655
 656     win.Show ()
 657
 658     match fileToOpen with
 659     | Some filepath -> loadFile filepath
 660     | None -> ()
 661
 662     app.Run ()