Parasitemia/ParasitemiaUI/GUI.fs

   1 module ParasitemiaUI.GUI
   2
   3 open System
   4 open System.IO
   5 open System.Linq
   6 open System.Windows
   7 open System.Windows.Media
   8 open System.Windows.Markup
   9 open System.Windows.Shapes
  10 open System.Windows.Controls
  11 open System.Diagnostics
  12 open Microsoft.Win32 // For the common dialogs.
  13
  14 open Emgu.CV.WPF
  15
  16 open Logger
  17
  18 open ParasitemiaCore.Config
  19 open ParasitemiaCore.Utils
  20 open Types
  21
  22 let run (defaultConfig : Config) (fileToOpen : string option) =
  23     let app = new Application ()
  24     let win = Views.MainWindow ()
  25
  26     let state = State.State defaultConfig
  27     let mutable currentScale = 1.
  28     let mutable displayHealthy = false
  29     let warningBelowNumberOfRBC = 1000
  30
  31     // Initializations.
  32     let canvasCurrentImageColor = win.canvasCurrentImage.Background
  33     win.menuHightlightRBC.IsChecked <- displayHealthy
  34
  35     // Utils.
  36     let extractRBCPreview (img : Emgu.CV.Image<Emgu.CV.Structure.Bgr, byte>) (rbc : RBC) : Emgu.CV.Image<Emgu.CV.Structure.Bgr, byte> =
  37         let rbcWidth = rbc.size.Width
  38         let rbcHeight = rbc.size.Height
  39         let x = rbc.center.X - rbcWidth / 2. |> roundInt
  40         let y = rbc.center.Y - rbcHeight / 2. |> roundInt
  41         let w = roundInt rbcWidth
  42         let h = roundInt rbcHeight
  43         img.GetSubRect (
  44             System.Drawing.Rectangle (
  45                 System.Drawing.Point ((if x < 0 then 0 else x), (if y < 0 then 0 else y)),
  46                 System.Drawing.Size ((if x + w >= img.Width then img.Width - x else w), (if y + h >= img.Height then img.Height - y else h))
  47             )
  48         )
  49
  50     let setRBCFrameStyle (srcImg : SourceImage) (rbc : RBC) (frame : Views.RBCFrame) =
  51         frame.Opacity <- if displayHealthy || rbc.setManually || rbc.infected then 1. else 0.
  52         let color = if rbc.infected then srcImg.InfectedRBCColor else srcImg.HealthyRBCColor
  53         frame.manuallyAdded.Visibility <- if rbc.setManually then Visibility.Visible else Visibility.Hidden
  54         frame.manuallyAdded.Fill <- color
  55         frame.border.Stroke <- color
  56
  57     let frameStrokeThickness (averageRBCSize : float) =
  58         max 1. (averageRBCSize / 60.)
  59
  60     let frameFontSize (averageRBCSize : float) =
  61         max 1. (averageRBCSize / 8.)
  62
  63     let RBCFrameFromExisting (srcImg : SourceImage) (rbc : RBC) (frame : Views.RBCFrame) (frameThickness : float) (fontSize : float) : Views.RBCFrame =
  64         frame.Visibility <- Visibility.Visible
  65         frame.Width <- rbc.size.Width
  66         frame.Height <- rbc.size.Height
  67         frame.Tag <- rbc
  68         setRBCFrameStyle srcImg rbc frame
  69         frame.border.StrokeThickness <- frameThickness
  70         frame.txtRBCNumber.Text <- string rbc.num
  71         frame.txtRBCNumber.FontSize <- fontSize
  72         frame
  73
  74     let updateDocumentStatus () =
  75         win.txtDocumentStatus.Text <- if state.FilePath = "" then "<New document>" else state.FilePath
  76
  77     let statusMessageTimer = Threading.DispatcherTimer ()
  78     statusMessageTimer.Tick.AddHandler (fun obj args -> statusMessageTimer.Stop (); win.txtMessageStatus.Text <- "")
  79     statusMessageTimer.Interval <- TimeSpan (0, 0, 2)
  80
  81     // To show a use message while a short period of time.
  82     let displayStatusMessage (message : string) =
  83         win.txtMessageStatus.Text <- message
  84         statusMessageTimer.Stop ()
  85         statusMessageTimer.Start ()
  86
  87     let highlightRBCFrame (frame : Views.RBCFrame) (highlight : bool) =
  88         let rbc = frame.Tag :?> RBC
  89         if highlight then
  90             frame.border.StrokeThickness <- 3. * frame.border.StrokeThickness
  91             if not rbc.infected && not rbc.setManually && not displayHealthy then frame.Opacity <- 1.
  92         else
  93             frame.border.StrokeThickness <- frame.border.StrokeThickness / 3.
  94             if not rbc.infected && not rbc.setManually && not displayHealthy then frame.Opacity <- 0.
  95
  96     let zoomToRBC (rbc : RBC) =
  97         win.scrollViewCurrentImage.ScrollToHorizontalOffset (rbc.center.X * currentScale - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
  98         win.scrollViewCurrentImage.ScrollToVerticalOffset (rbc.center.Y * currentScale - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
  99
 100     let txtImageName_TextChanged =
 101         TextChangedEventHandler (fun obj args -> state.CurrentImage |> Option.iter (fun srcImg -> state.SetName srcImg win.txtImageName.Text))
 102
 103     let updateCurrentImageInformation () =
 104         win.txtImageName.TextChanged.RemoveHandler (txtImageName_TextChanged)
 105         win.txtImageInformation1.Inlines.Clear ()
 106         win.txtImageInformation2.Inlines.Clear ()
 107         win.txtImageName.Text <- ""
 108
 109         match state.CurrentImage with
 110         | Some srcImg ->
 111             win.gridImageInformation.Visibility <- Visibility.Visible
 112             win.txtImageName.Text <- srcImg.Name
 113             win.txtImageName.TextChanged.AddHandler txtImageName_TextChanged
 114
 115             // The left part.
 116             let parasitemiaStr = Utils.percentText srcImg.ImageParasitemia
 117             win.txtImageInformation1.Inlines.Add (Documents.Run ("Parasitemia: ", FontWeight = FontWeights.Bold))
 118             win.txtImageInformation1.Inlines.Add parasitemiaStr
 119             win.txtImageInformation1.Inlines.Add (Documents.LineBreak ())
 120
 121             win.txtImageInformation1.Inlines.Add (Documents.Run ("Last analysis: ", FontWeight = FontWeights.Bold))
 122             win.txtImageInformation1.Inlines.Add (Documents.Run (if srcImg.DateLastAnalysis.Ticks = 0L then "<Never>" else string (srcImg.DateLastAnalysis.ToLocalTime())))
 123
 124             // The right part part.
 125             win.txtImageInformation2.Inlines.Add (Documents.Run ("Added infected erythrocyte: ", FontWeight = FontWeights.Bold))
 126             win.txtImageInformation2.Inlines.Add (Documents.Run ((srcImg.ImageNbManuallyChangedRBCStr true) + " " + (srcImg.ImageManuallyChangedRBCStr true)))
 127             win.txtImageInformation2.Inlines.Add (Documents.LineBreak ())
 128             win.txtImageInformation2.Inlines.Add (Documents.Run ("Removed infected erythrocyte: ", FontWeight = FontWeights.Bold))
 129             win.txtImageInformation2.Inlines.Add (Documents.Run ((srcImg.ImageNbManuallyChangedRBCStr false) + " " + (srcImg.ImageManuallyChangedRBCStr false)))
 130
 131         | _ ->
 132             win.gridImageInformation.Visibility <- Visibility.Hidden
 133
 134     let updateGlobalParasitemia () =
 135         win.txtGlobalParasitemia.Inlines.Clear ()
 136         let total, infected = state.GlobalParasitemia
 137         win.txtGlobalParasitemia.Inlines.Add (Documents.Run (Utils.percentText (total, infected), FontWeight = FontWeights.Bold))
 138         if total > 0 && total < warningBelowNumberOfRBC then
 139             win.txtGlobalParasitemia.Inlines.Add (
 140                 Documents.Run (
 141                     sprintf " Warning: the number of erythrocytes should be above %d" warningBelowNumberOfRBC,
 142                     FontWeight = FontWeights.Bold,
 143                     Foreground = Brushes.Red
 144                 )
 145             )
 146
 147     let updateViewportPreview () =
 148         for preview in win.stackPreviews.Children |> Seq.cast<Views.ImageSourcePreview> do
 149             let srcImg = preview.Tag :?> SourceImage
 150             if Some srcImg = state.CurrentImage then
 151                 preview.viewport.Visibility <- Visibility.Visible
 152
 153                 let canvasWidth = win.canvasCurrentImage.ActualWidth * currentScale
 154                 let canvasHeight = win.canvasCurrentImage.ActualHeight * currentScale
 155                 let previewWidth = (preview.ActualWidth - preview.BorderThickness.Left - preview.BorderThickness.Right)
 156                 let previewHeight = (preview.ActualHeight - preview.BorderThickness.Top - preview.BorderThickness.Bottom)
 157
 158                 let marginLeft = previewWidth * (win.scrollViewCurrentImage.HorizontalOffset - win.borderCurrentImage.BorderThickness.Left) / canvasWidth - 2.
 159                 let marginRight = previewWidth * (canvasWidth - (win.scrollViewCurrentImage.HorizontalOffset - win.borderCurrentImage.BorderThickness.Right) - win.scrollViewCurrentImage.ViewportWidth) / canvasWidth - 2.
 160                 let marginTop = previewHeight * (win.scrollViewCurrentImage.VerticalOffset - win.borderCurrentImage.BorderThickness.Top) / canvasHeight - 2.
 161                 let marginBottom = previewHeight * (canvasHeight - (win.scrollViewCurrentImage.VerticalOffset - win.borderCurrentImage.BorderThickness.Bottom) - win.scrollViewCurrentImage.ViewportHeight) / canvasHeight - 2.
 162
 163                 preview.viewport.Margin <-
 164                     Thickness (
 165                         marginLeft,
 166                         marginTop,
 167                         marginRight,
 168                         marginBottom
 169                     )
 170             else
 171                 preview.viewport.Visibility <- Visibility.Hidden
 172
 173     let rec setAsInfected (srcImg : SourceImage) (rbc : RBC) (infected : bool) =
 174         state.SetAsInfected rbc infected
 175         win.canvasCurrentImage.Children
 176         |> Seq.cast<Views.RBCFrame>
 177         |> Seq.iter (
 178             fun frame ->
 179                 if (frame.Tag :?> RBC) = rbc then
 180                     setRBCFrameStyle srcImg rbc frame
 181         )
 182         updateRBCFramesPreview ()
 183         updateCurrentImageInformation ()
 184         updateGlobalParasitemia ()
 185
 186     and RBCFrame (srcImg : SourceImage) (rbc : RBC) (frameThickness : float) (fontSize : float) : Views.RBCFrame =
 187         let frame = RBCFrameFromExisting srcImg rbc (Views.RBCFrame ()) frameThickness fontSize
 188         frame.SetValue (Panel.ZIndexProperty, Int32.MaxValue - rbc.num) // To be sure the
 189         frame.menuRBCSetAsHealthy.Click.AddHandler (fun obj args -> setAsInfected srcImg (frame.Tag :?> RBC) false)
 190         frame.menuRBCSetAsInfected.Click.AddHandler (fun obj args -> setAsInfected srcImg (frame.Tag :?> RBC) true)
 191         frame.ContextMenuOpening.AddHandler (
 192             fun obj args ->
 193                 if (frame.Tag :?> RBC).infected then
 194                     frame.menuRBCSetAsHealthy.Visibility <- Visibility.Visible
 195                     frame.menuRBCSetAsInfected.Visibility <- Visibility.Collapsed
 196                 else
 197                     frame.menuRBCSetAsHealthy.Visibility <- Visibility.Collapsed
 198                     frame.menuRBCSetAsInfected.Visibility <- Visibility.Visible
 199         )
 200         frame.ContextMenuClosing.AddHandler (fun obj args -> if not frame.IsMouseOver then highlightRBCFrame frame false )
 201         frame.MouseEnter.AddHandler (fun obj args -> highlightRBCFrame frame true)
 202         frame.MouseLeave.AddHandler (fun obj args -> if not frame.grid.ContextMenu.IsOpen then highlightRBCFrame frame false)
 203         frame
 204
 205     and updateRBCFramesPreview () =
 206         match state.CurrentImage with
 207         | Some srcImg ->
 208             let mutable currentPreview = 0
 209             for rbc in srcImg.RBCs |> List.filter (fun rbc -> displayHealthy || rbc.infected) do
 210                 let previewInfected =
 211                     if currentPreview < win.stackRBC.Children.Count then
 212                         RBCFrameFromExisting srcImg rbc (win.stackRBC.Children.[currentPreview] :?> Views.RBCFrame) 1. 12.
 213                     else
 214                         let f = RBCFrame srcImg rbc 1. 12.
 215                         f.MouseLeftButtonUp.AddHandler (fun obj args -> zoomToRBC (f.Tag :?> RBC))
 216                         win.stackRBC.Children.Add f |> ignore
 217                         f
 218
 219                 currentPreview <- currentPreview + 1
 220
 221                 previewInfected.Height <- win.stackRBC.ActualHeight
 222                 previewInfected.Width <- win.stackRBC.ActualHeight * rbc.size.Width / rbc.size.Height
 223                 previewInfected.border.Fill <- ImageBrush (BitmapSourceConvert.ToBitmapSource (extractRBCPreview srcImg.Img rbc))
 224
 225             win.stackRBC.Children.RemoveRange (currentPreview, win.stackRBC.Children.Count - currentPreview)
 226         | _ -> ()
 227
 228         updateViewportPreview ()
 229
 230     let updateRBCFramesCurrent () =
 231         match state.CurrentImage with
 232         | Some srcImg ->
 233             let mutable currentCanvas = 0
 234             let strokeThickness = frameStrokeThickness srcImg.AverageRBCSize
 235             let fontSize = frameFontSize srcImg.AverageRBCSize
 236             for rbc in srcImg.RBCs do
 237                 let frame =
 238                     if currentCanvas < win.canvasCurrentImage.Children.Count then
 239                         RBCFrameFromExisting srcImg rbc (win.canvasCurrentImage.Children.[currentCanvas] :?> Views.RBCFrame) strokeThickness fontSize
 240                     else
 241                         let f = RBCFrame srcImg rbc strokeThickness fontSize
 242                         win.canvasCurrentImage.Children.Add f |> ignore
 243                         f
 244
 245                 currentCanvas <- currentCanvas + 1
 246
 247                 Canvas.SetLeft (frame, rbc.center.X - rbc.size.Width / 2.)
 248                 Canvas.SetTop (frame, rbc.center.Y - rbc.size.Height / 2.)
 249
 250             for i in currentCanvas .. win.canvasCurrentImage.Children.Count - 1 do
 251                 win.canvasCurrentImage.Children.[i].Visibility <- Visibility.Hidden
 252         | _ -> ()
 253
 254     let askDocumentPathToSave () : string option =
 255         let dialog = SaveFileDialog (AddExtension = true, DefaultExt = PiaZ.extension, Filter = PiaZ.filter)
 256
 257         if state.FilePath <> "" then
 258             dialog.FileName <- FileInfo(state.FilePath).Name
 259         elif state.PatientID <> "" then
 260             dialog.FileName <- state.PatientID + PiaZ.extension
 261
 262         let res = dialog.ShowDialog ()
 263         if res.HasValue && res.Value then
 264             Some dialog.FileName
 265         else
 266             None
 267
 268     let saveCurrentDocument () =
 269         try
 270             if state.FilePath = "" then
 271                 match askDocumentPathToSave () with
 272                 | Some filepath ->
 273                     state.FilePath <- filepath
 274                     state.Save ()
 275                 | _ -> ()
 276             else
 277                 state.Save ()
 278             updateDocumentStatus ()
 279             displayStatusMessage "Document saved"
 280         with
 281         | :? IOException as ex ->
 282             Log.Error "%O" ex
 283             MessageBox.Show (sprintf "The document cannot be save in \"%s\"" state.FilePath, "Error saving the document", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 284
 285     let saveCurrentDocumentAsNewFile () =
 286         match askDocumentPathToSave () with
 287         | Some filepath ->
 288             state.FilePath <- filepath
 289             saveCurrentDocument ()
 290         | _ -> ()
 291
 292     // Ask the use to save the current document if neccessary.
 293     let askSaveCurrent () =
 294         if state.AlteredSinceLastSave then
 295             match MessageBox.Show ("Would you like to save the current document?", "Saving the current document", MessageBoxButton.YesNo, MessageBoxImage.Question) with
 296             | MessageBoxResult.Yes -> saveCurrentDocument ()
 297             | _ -> ()
 298
 299     let updateCurrentImage () =
 300         match state.CurrentImage with
 301         | Some srcImg ->
 302             win.imgLogos.Visibility <- Visibility.Collapsed
 303
 304             // Highlight the preview.
 305             win.stackPreviews.Children
 306             |> Seq.cast<Views.ImageSourcePreview>
 307             |> Seq.iter (fun preview -> preview.border.BorderThickness <- Thickness (if preview.Tag = (srcImg :> Object) then 3. else 0.))
 308
 309             win.canvasCurrentImage.Height <- float srcImg.Img.Height
 310             win.canvasCurrentImage.Width <- float srcImg.Img.Width
 311             win.canvasCurrentImage.Background <- ImageBrush (BitmapSourceConvert.ToBitmapSource (srcImg.Img))
 312
 313             updateRBCFramesCurrent ()
 314             updateRBCFramesPreview ()
 315
 316         | None ->
 317             win.imgLogos.Visibility <- Visibility.Visible
 318
 319             win.stackRBC.Children.Clear ()
 320             win.canvasCurrentImage.Children.Clear ()
 321             win.canvasCurrentImage.Background <- canvasCurrentImageColor
 322
 323         updateCurrentImageInformation ()
 324
 325     let setCurrentImage (srcImg : SourceImage) =
 326         if state.CurrentImage.IsNone || state.CurrentImage.Value <> srcImg then
 327             state.CurrentImage <- Some srcImg
 328             updateCurrentImage ()
 329
 330     let addPreview (srcImg : SourceImage) =
 331         let imgCtrl = Views.ImageSourcePreview (Margin = Thickness 3.)
 332
 333         imgCtrl.menuRemoveImage.Click.AddHandler (
 334             fun obj args ->
 335                 win.stackPreviews.Children.Remove (imgCtrl)
 336                 let srcImg = imgCtrl.Tag :?> SourceImage
 337                 let currentRemoved = Some srcImg = state.CurrentImage
 338                 state.RemoveSourceImage srcImg
 339                 if currentRemoved then
 340                     updateCurrentImage ()
 341
 342                 updateGlobalParasitemia ()
 343
 344                 // Update image numbers.
 345                 win.stackPreviews.Children |> Seq.cast<Views.ImageSourcePreview> |> Seq.iter (fun imgPreview -> imgPreview.txtImageNumber.Text <- (imgPreview.Tag :?> SourceImage).Num.ToString ())
 346         )
 347
 348         imgCtrl.Tag <- srcImg
 349         imgCtrl.txtImageNumber.Text <- string srcImg.Num
 350         let width = 200
 351         let height = srcImg.Img.Height * width / srcImg.Img.Width
 352         imgCtrl.imagePreview.Source <- BitmapSourceConvert.ToBitmapSource (srcImg.Img.Resize (width, height, Emgu.CV.CvEnum.Inter.Cubic))
 353         win.stackPreviews.Children.Add imgCtrl |> ignore
 354
 355         // Zoom to a mouse position into the control 'imgCtrl'.
 356         let zoomTo (mousePos : Point) =
 357             let canvasW = win.canvasCurrentImage.ActualWidth * currentScale
 358             let canvasH = win.canvasCurrentImage.ActualHeight * currentScale
 359             let centerX = (mousePos.X - imgCtrl.BorderThickness.Left) / (imgCtrl.ActualWidth - imgCtrl.BorderThickness.Left) * canvasW
 360             let centerY = (mousePos.Y - imgCtrl.BorderThickness.Top) / (imgCtrl.ActualHeight - imgCtrl.BorderThickness.Top) * canvasH
 361             win.scrollViewCurrentImage.ScrollToHorizontalOffset (centerX - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
 362             win.scrollViewCurrentImage.ScrollToVerticalOffset (centerY - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
 363
 364         imgCtrl.MouseLeftButtonDown.AddHandler (
 365             fun obj args ->
 366                 setCurrentImage (state.SourceImages |> Seq.find (fun srcImg -> (srcImg :> Object) = imgCtrl.Tag))
 367                 imgCtrl.UpdateLayout ()
 368                 zoomTo (args.GetPosition (imgCtrl))
 369                 imgCtrl.CaptureMouse () |> ignore
 370         )
 371
 372         imgCtrl.MouseMove.AddHandler (
 373             fun obj args ->
 374                 if imgCtrl.IsMouseCaptured then
 375                     zoomTo (args.GetPosition imgCtrl)
 376         )
 377
 378         imgCtrl.MouseLeftButtonUp.AddHandler (
 379             fun obj args ->
 380                 if imgCtrl.IsMouseCaptured then
 381                     imgCtrl.ReleaseMouseCapture ()
 382         )
 383
 384     let updatePreviews () =
 385         win.stackPreviews.Children.Clear ()
 386         for srcImg in state.SourceImages do
 387             addPreview srcImg
 388         updateCurrentImage ()
 389
 390     let updateGUI () =
 391         win.txtPatient.Text <- state.PatientID
 392         updatePreviews ()
 393         updateGlobalParasitemia ()
 394         updateDocumentStatus ()
 395
 396     let loadFile (filepath : string) =
 397         askSaveCurrent ()
 398         let previousFilePath = state.FilePath
 399         try
 400             state.FilePath <- filepath
 401             state.Load ()
 402             updateGUI ()
 403         with
 404         | :? IOException as ex ->
 405             Log.Error "%O" ex
 406             state.FilePath <- previousFilePath
 407             MessageBox.Show (sprintf "The document cannot be loaded from \"%s\"" filepath, "Error loading the document", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 408
 409     let askLoadFile () =
 410         let dialog = OpenFileDialog (Filter = PiaZ.filter)
 411         let res = dialog.ShowDialog ()
 412         if res.HasValue && res.Value then
 413             loadFile dialog.FileName
 414
 415     let newFile () =
 416         askSaveCurrent ()
 417         state.Reset ()
 418         updateGUI ()
 419
 420     let exportResults () =
 421         let extension = ".txt"
 422         let dialog = SaveFileDialog (AddExtension = true, DefaultExt = extension)
 423
 424         if state.FilePath <> "" then
 425             dialog.FileName <- Path.GetFileNameWithoutExtension state.FilePath + extension
 426         elif state.PatientID <> "" then
 427             dialog.FileName <- state.PatientID + extension
 428
 429         let res = dialog.ShowDialog ()
 430         if res.HasValue && res.Value then
 431             try
 432                 Export.exportResults state dialog.FileName
 433             with
 434             | :? IOException as ex ->
 435                 Log.Error "%O" ex
 436                 MessageBox.Show (sprintf "The results cannot be exported in \"%s\"" state.FilePath, "Error exporting the files", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 437
 438     let importImage () =
 439         let dialog = OpenFileDialog (Filter = "Image Files|*.png;*.jpg;*.tif;*.tiff", Multiselect = true)
 440         let res = dialog.ShowDialog ()
 441         if res.HasValue && res.Value then
 442             let noSourceImage = state.SourceImages.Count () = 0
 443
 444             for filename in dialog.FileNames do
 445                 try
 446                     let srcImg = state.AddSourceImage filename defaultConfig
 447                     addPreview srcImg
 448                 with
 449                 | _ as ex ->
 450                     Log.Error "%O" ex
 451                     MessageBox.Show (sprintf "Unable to read the image from \"%s\"" filename, "Error adding an image", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 452
 453             updateGlobalParasitemia ()
 454
 455             if noSourceImage then
 456                 updateCurrentImage ()
 457
 458     let showAnalysisWindow () =
 459         if Analysis.showWindow win state then
 460             updateGlobalParasitemia ()
 461             updateCurrentImage ()
 462
 463     let setHighlightRBC (highlight : bool) =
 464         displayHealthy <- highlight
 465         updateRBCFramesPreview ()
 466         updateRBCFramesCurrent ()
 467
 468     win.txtPatient.TextChanged.AddHandler (fun obj args -> state.PatientID <- win.txtPatient.Text)
 469
 470     win.menuExit.Click.AddHandler (fun obj args -> win.Close ())
 471     win.menuSave.Click.AddHandler (fun obj args -> saveCurrentDocument ())
 472     win.menuSaveAs.Click.AddHandler (fun obj args -> saveCurrentDocumentAsNewFile ())
 473     win.menuOpen.Click.AddHandler (fun obj args -> askLoadFile ())
 474     win.menuNew.Click.AddHandler (fun obj args -> newFile ())
 475     win.menuExportResults.Click.AddHandler (fun obj args -> exportResults ())
 476
 477     win.menuAddSourceImage.Click.AddHandler (fun obj args -> importImage ())
 478
 479     win.menuAnalysis.SubmenuOpened.AddHandler (fun obj args -> win.menuStartAnalysis.IsEnabled <- state.SourceImages.Count () > 0)
 480
 481     win.menuStartAnalysis.Click.AddHandler (fun obj args -> showAnalysisWindow ())
 482
 483     win.menuHightlightRBC.Click.AddHandler (fun obj args -> setHighlightRBC win.menuHightlightRBC.IsChecked)
 484
 485     win.menuAbout.Click.AddHandler (fun obj args -> About.showWindow win)
 486
 487     win.Closing.AddHandler (fun obj args -> askSaveCurrent ())
 488
 489     // Zoom on the current image.
 490     let adjustCurrentImageBorders (deltaX : float) (deltaY : float) =
 491         win.borderCurrentImage.BorderThickness <-
 492             Thickness (
 493                 (win.scrollViewCurrentImage.ViewportWidth + deltaX) / 2.,
 494                 (win.scrollViewCurrentImage.ViewportHeight + deltaY) / 2.,
 495                 (win.scrollViewCurrentImage.ViewportWidth + deltaX) / 2.,
 496                 (win.scrollViewCurrentImage.ViewportHeight + deltaY) / 2.
 497             )
 498
 499     win.canvasCurrentImage.SizeChanged.AddHandler (
 500         fun obj args ->
 501             let deltaX = args.NewSize.Width - args.PreviousSize.Width
 502             let deltaY = args.NewSize.Height - args.PreviousSize.Height
 503             if deltaX > 0.5 || deltaY > 0.5 then
 504                 adjustCurrentImageBorders 0.0 0.0
 505                 // Center the view at the center of the image initialy.
 506                 win.scrollViewCurrentImage.UpdateLayout ()
 507                 win.scrollViewCurrentImage.ScrollToHorizontalOffset (win.borderCurrentImage.ActualWidth / 2. - win.scrollViewCurrentImage.ViewportWidth / 2.)
 508                 win.scrollViewCurrentImage.ScrollToVerticalOffset (win.borderCurrentImage.ActualHeight / 2. - win.scrollViewCurrentImage.ViewportHeight / 2.)
 509     )
 510
 511     win.scrollViewCurrentImage.SizeChanged.AddHandler (
 512         fun obj args ->
 513             let deltaX = args.NewSize.Width - args.PreviousSize.Width
 514             let deltaY = args.NewSize.Height - args.PreviousSize.Height
 515             adjustCurrentImageBorders deltaX deltaY
 516             win.scrollViewCurrentImage.ScrollToHorizontalOffset (win.scrollViewCurrentImage.HorizontalOffset + deltaX / 8.)
 517             win.scrollViewCurrentImage.ScrollToVerticalOffset (win.scrollViewCurrentImage.VerticalOffset + deltaY / 8.)
 518     )
 519
 520     let mutable maxScale = 4.
 521     let mutable minScale = 0.25
 522     let currentImageScaleTransform = ScaleTransform ()
 523     win.canvasCurrentImage.LayoutTransform <- currentImageScaleTransform
 524     win.borderCurrentImage.PreviewMouseWheel.AddHandler (
 525         fun _obj args ->
 526             let scaleFactor = if args.Delta > 0 then 2.0 else 0.5
 527             if scaleFactor > 1. && currentScale < maxScale || scaleFactor < 1. && currentScale > minScale then
 528                 let previousScale = currentScale
 529                 currentScale <-
 530                     let newScale = currentScale * scaleFactor
 531                     if newScale > maxScale then maxScale elif newScale < minScale then minScale else newScale
 532                 let realScaleFactor = currentScale / previousScale
 533
 534                 let centerX = win.scrollViewCurrentImage.HorizontalOffset + win.scrollViewCurrentImage.ViewportWidth / 2. - win.borderCurrentImage.BorderThickness.Left
 535                 let centerY = win.scrollViewCurrentImage.VerticalOffset + win.scrollViewCurrentImage.ViewportHeight / 2. - win.borderCurrentImage.BorderThickness.Top
 536
 537                 currentImageScaleTransform.ScaleX <- currentScale
 538                 currentImageScaleTransform.ScaleY <- currentScale
 539
 540                 win.scrollViewCurrentImage.ScrollToHorizontalOffset (centerX * realScaleFactor - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
 541                 win.scrollViewCurrentImage.ScrollToVerticalOffset (centerY * realScaleFactor - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
 542
 543             args.Handled <- true
 544     )
 545
 546     // Pan on the current image.
 547     let mutable scrollStartPosition = Point (0., 0.)
 548     let mutable scrollStartOffsetX = 0.
 549     let mutable scrollStartOffsetY = 0.
 550     win.borderCurrentImage.PreviewMouseLeftButtonDown.AddHandler (
 551         fun _obj args ->
 552             scrollStartPosition <- args.GetPosition win.scrollViewCurrentImage
 553             scrollStartOffsetX <- win.scrollViewCurrentImage.HorizontalOffset
 554             scrollStartOffsetY <- win.scrollViewCurrentImage.VerticalOffset
 555             win.borderCurrentImage.Cursor <- Input.Cursors.ScrollAll
 556             win.borderCurrentImage.CaptureMouse () |> ignore
 557             args.Handled <- true
 558     )
 559
 560     win.borderCurrentImage.PreviewMouseMove.AddHandler (
 561         fun _obj args ->
 562             if win.borderCurrentImage.IsMouseCaptured then
 563                 let position = args.GetPosition win.scrollViewCurrentImage
 564                 let deltaX = scrollStartPosition.X - position.X
 565                 let deltaY = scrollStartPosition.Y - position.Y
 566                 win.scrollViewCurrentImage.ScrollToHorizontalOffset (deltaX + scrollStartOffsetX)
 567                 win.scrollViewCurrentImage.ScrollToVerticalOffset (deltaY + scrollStartOffsetY)
 568
 569                 args.Handled <- true
 570     )
 571
 572     win.borderCurrentImage.PreviewMouseLeftButtonUp.AddHandler (
 573         fun _obj args ->
 574             if win.borderCurrentImage.IsMouseCaptured then
 575                 win.borderCurrentImage.Cursor <- Input.Cursors.Arrow
 576                 win.borderCurrentImage.ReleaseMouseCapture ()
 577                 args.Handled <- true
 578     )
 579
 580     // Shortcuts.
 581     // Save.
 582     win.InputBindings.Add (
 583         Input.KeyBinding (
 584             ViewModule.FunCommand ((fun obj -> saveCurrentDocument ()), (fun obj -> true)),
 585             Input.KeyGesture (Input.Key.S, Input.ModifierKeys.Control)
 586         )
 587     ) |> ignore
 588
 589     // Save as.
 590     win.InputBindings.Add (
 591         Input.KeyBinding (
 592             ViewModule.FunCommand ((fun obj -> saveCurrentDocumentAsNewFile ()), (fun obj -> true)),
 593             Input.KeyGesture (Input.Key.S, Input.ModifierKeys.Control ||| Input.ModifierKeys.Shift)
 594         )
 595     ) |> ignore
 596
 597     // Open.
 598     win.InputBindings.Add (
 599         Input.KeyBinding (
 600             ViewModule.FunCommand ((fun obj -> askLoadFile ()), (fun obj -> true)),
 601             Input.KeyGesture (Input.Key.O, Input.ModifierKeys.Control)
 602         )
 603     ) |> ignore
 604
 605     // New file.
 606     win.InputBindings.Add (
 607         Input.KeyBinding (
 608             ViewModule.FunCommand ((fun obj -> newFile ()), (fun obj -> true)),
 609             Input.KeyGesture (Input.Key.N, Input.ModifierKeys.Control)
 610         )
 611     ) |> ignore
 612
 613     // Export results.
 614     win.InputBindings.Add (
 615         Input.KeyBinding (
 616             ViewModule.FunCommand ((fun obj -> exportResults ()), (fun obj -> true)),
 617             Input.KeyGesture (Input.Key.E, Input.ModifierKeys.Control)
 618         )
 619     ) |> ignore
 620
 621     // Import an image.
 622     win.InputBindings.Add (
 623         Input.KeyBinding (
 624             ViewModule.FunCommand ((fun obj -> importImage ()), (fun obj -> true)),
 625             Input.KeyGesture (Input.Key.A, Input.ModifierKeys.Control)
 626         )
 627     ) |> ignore
 628
 629     // Show analysis dialog.
 630     win.InputBindings.Add (
 631         Input.KeyBinding (
 632             ViewModule.FunCommand ((fun obj -> showAnalysisWindow ()), (fun obj -> state.SourceImages.Count () > 0)),
 633             Input.KeyGesture (Input.Key.Y, Input.ModifierKeys.Control)
 634         )
 635     ) |> ignore
 636
 637     // Toggle RBC highlight.
 638     win.InputBindings.Add (
 639         Input.KeyBinding (
 640             ViewModule.FunCommand (
 641                 (
 642                     fun obj ->
 643                         win.menuHightlightRBC.IsChecked <- not win.menuHightlightRBC.IsChecked
 644                         setHighlightRBC win.menuHightlightRBC.IsChecked
 645                 ),
 646                 (fun obj -> true)
 647             ),
 648             Input.KeyGesture (Input.Key.H, Input.ModifierKeys.Control)
 649         )
 650     ) |> ignore
 651
 652     // Viewport preview.
 653     win.scrollViewCurrentImage.ScrollChanged.AddHandler (fun obj args -> updateViewportPreview ())
 654
 655     updateDocumentStatus ()
 656     win.gridImageInformation.Visibility <- Visibility.Hidden
 657
 658     win.Show ()
 659
 660     match fileToOpen with
 661     | Some filepath -> loadFile filepath
 662     | None -> ()
 663
 664     app.Run ()