Parasitemia/ParasitemiaUI/GUI.fs

   1 module ParasitemiaUI.GUI
   2
   3 open System
   4 open System.IO
   5 open System.Linq
   6 open System.Windows
   7 open System.Windows.Media
   8 open System.Windows.Markup
   9 open System.Windows.Shapes
  10 open System.Windows.Controls
  11 open System.Diagnostics
  12 open Microsoft.Win32 // For the common dialogs.
  13
  14 open Emgu.CV.WPF
  15
  16 open Logger
  17
  18 open ParasitemiaCore.Config
  19 open ParasitemiaCore.Utils
  20 open Types
  21
  22 let run (defaultConfig: Config) (fileToOpen: string option) =
  23     let app = new Application()
  24     let win = Views.MainWindow()
  25
  26     let state = State.State(defaultConfig)
  27     let mutable currentScale = 1.
  28     let mutable displayHealthy = false
  29     let warningBelowNumberOfRBC = 1000
  30
  31     // Initializations.
  32     let canvasCurrentImageColor = win.canvasCurrentImage.Background
  33     win.menuHightlightRBC.IsChecked <- displayHealthy
  34
  35     // Utils.
  36     let extractRBCPreview (img: Emgu.CV.Image<Emgu.CV.Structure.Bgr, byte>) (rbc: RBC) : Emgu.CV.Image<Emgu.CV.Structure.Bgr, byte> =
  37         let rbcWidth = rbc.size.Width
  38         let rbcHeight = rbc.size.Height
  39         let x = rbc.center.X - rbcWidth / 2. |> roundInt
  40         let y = rbc.center.Y - rbcHeight / 2. |> roundInt
  41         let w = roundInt rbcWidth
  42         let h = roundInt rbcHeight
  43         img.GetSubRect(System.Drawing.Rectangle(System.Drawing.Point((if x < 0 then 0 else x), (if y < 0 then 0 else y)),
  44                                                 System.Drawing.Size((if x + w >= img.Width then img.Width - x else w),
  45                                                                     (if y + h >= img.Height then img.Height - y else h))))
  46
  47     let setRBCFrameStyle (srcImg: SourceImage) (rbc: RBC) (frame: Views.RBCFrame) =
  48         frame.Opacity <- if displayHealthy || rbc.setManually || rbc.infected then 1. else 0.
  49         let color = if rbc.infected then srcImg.InfectedRBCColor else srcImg.HealthyRBCColor
  50         frame.manuallyAdded.Visibility <- if rbc.setManually then Visibility.Visible else Visibility.Hidden
  51         frame.manuallyAdded.Fill <- color
  52         frame.border.Stroke <- color
  53
  54     let RBCFrameFromExisting (srcImg: SourceImage) (rbc: RBC) (frame: Views.RBCFrame) : Views.RBCFrame =
  55         frame.Visibility <- Visibility.Visible
  56         frame.Height <- rbc.size.Height
  57         frame.Width <- rbc.size.Width
  58         frame.Tag <- rbc
  59         setRBCFrameStyle srcImg rbc frame
  60         frame.border.StrokeThickness <- 1.
  61         frame.txtRBCNumber.Text <- rbc.num.ToString()
  62         frame
  63
  64     let updateDocumentStatus () =
  65         win.txtDocumentStatus.Text <- if state.FilePath = "" then "<New document>" else state.FilePath
  66
  67     let statusMessageTimer = Threading.DispatcherTimer()
  68     statusMessageTimer.Tick.AddHandler(fun obj args -> statusMessageTimer.Stop(); win.txtMessageStatus.Text <- "")
  69     statusMessageTimer.Interval <- TimeSpan(0, 0, 2)
  70     let displayStatusMessage (message: string) =
  71         win.txtMessageStatus.Text <- message
  72         statusMessageTimer.Stop()
  73         statusMessageTimer.Start()
  74
  75     let highlightRBCFrame (frame: Views.RBCFrame) (highlight: bool) =
  76         let rbc = frame.Tag :?> RBC
  77         if highlight
  78         then
  79             frame.border.StrokeThickness <- 3.
  80             if not rbc.infected && not rbc.setManually && not displayHealthy then frame.Opacity <- 1.
  81         else
  82             frame.border.StrokeThickness <- 1.
  83             if not rbc.infected && not rbc.setManually && not displayHealthy then frame.Opacity <- 0.
  84
  85     let zoomToRBC (rbc: RBC) =
  86         win.scrollViewCurrentImage.ScrollToHorizontalOffset(rbc.center.X * currentScale - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
  87         win.scrollViewCurrentImage.ScrollToVerticalOffset(rbc.center.Y * currentScale - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
  88
  89
  90     let txtImageName_TextChanged =
  91         TextChangedEventHandler(fun obj args -> state.CurrentImage |> Option.iter(fun srcImg -> state.SetName srcImg win.txtImageName.Text))
  92
  93     let updateCurrentImageInformation () =
  94         win.txtImageName.TextChanged.RemoveHandler(txtImageName_TextChanged)
  95         win.txtImageInformation1.Inlines.Clear()
  96         win.txtImageInformation2.Inlines.Clear()
  97         win.txtImageName.Text <- ""
  98
  99         match state.CurrentImage with
 100         | Some srcImg ->
 101             win.gridImageInformation.Visibility <- Visibility.Visible
 102             win.txtImageName.Text <- srcImg.name
 103             win.txtImageName.TextChanged.AddHandler(txtImageName_TextChanged)
 104
 105             // The left part.
 106             let parasitemiaStr = Utils.percentText (state.ImageParasitemia srcImg)
 107             win.txtImageInformation1.Inlines.Add(Documents.Run("Parasitemia: ", FontWeight = FontWeights.Bold))
 108             win.txtImageInformation1.Inlines.Add(parasitemiaStr)
 109             win.txtImageInformation1.Inlines.Add(Documents.LineBreak())
 110
 111             win.txtImageInformation1.Inlines.Add(Documents.Run("Last analysis: ", FontWeight = FontWeights.Bold))
 112             win.txtImageInformation1.Inlines.Add(Documents.Run(if srcImg.dateLastAnalysis.Ticks = 0L then "<Never>" else srcImg.dateLastAnalysis.ToLocalTime().ToString()))
 113
 114             // The right part part.
 115             win.txtImageInformation2.Inlines.Add(Documents.Run("Added infected erythrocyte: ", FontWeight = FontWeights.Bold))
 116             win.txtImageInformation2.Inlines.Add(Documents.Run((state.ImageNbManuallyChangedRBCStr srcImg true) + " " + (state.ImageManuallyChangedRBCStr srcImg true)))
 117             win.txtImageInformation2.Inlines.Add(Documents.LineBreak())
 118             win.txtImageInformation2.Inlines.Add(Documents.Run("Removed infected erythrocyte: ", FontWeight = FontWeights.Bold))
 119             win.txtImageInformation2.Inlines.Add(Documents.Run((state.ImageNbManuallyChangedRBCStr srcImg false) + " " + (state.ImageManuallyChangedRBCStr srcImg false)))
 120
 121         | _ ->
 122             win.gridImageInformation.Visibility <- Visibility.Hidden
 123
 124     let updateGlobalParasitemia () =
 125         win.txtGlobalParasitemia.Inlines.Clear()
 126         let total, infected = state.GlobalParasitemia
 127         win.txtGlobalParasitemia.Inlines.Add(Documents.Run(Utils.percentText (total, infected), FontWeight = FontWeights.Bold))
 128         if total > 0 && total < warningBelowNumberOfRBC
 129         then
 130             win.txtGlobalParasitemia.Inlines.Add(
 131                 Documents.Run(
 132                     sprintf " Warning: the number of erythrocytes should be above %d" warningBelowNumberOfRBC,
 133                     FontWeight = FontWeights.Bold,
 134                     Foreground = Brushes.Red))
 135
 136     let updateViewportPreview () =
 137         for preview in win.stackPreviews.Children |> Seq.cast<Views.ImageSourcePreview> do
 138             let srcImg = preview.Tag :?> SourceImage
 139             if Some srcImg = state.CurrentImage then
 140                 preview.viewport.Visibility <- Visibility.Visible
 141
 142                 let canvasWidth = win.canvasCurrentImage.ActualWidth * currentScale
 143                 let canvasHeight = win.canvasCurrentImage.ActualHeight * currentScale
 144                 let previewWidth = (preview.ActualWidth - preview.BorderThickness.Left - preview.BorderThickness.Right)
 145                 let previewHeight = (preview.ActualHeight - preview.BorderThickness.Top - preview.BorderThickness.Bottom)
 146
 147                 let marginLeft = previewWidth * (win.scrollViewCurrentImage.HorizontalOffset - win.borderCurrentImage.BorderThickness.Left) / canvasWidth - 2.
 148                 let marginRight = previewWidth * (canvasWidth - (win.scrollViewCurrentImage.HorizontalOffset - win.borderCurrentImage.BorderThickness.Right) - win.scrollViewCurrentImage.ViewportWidth) / canvasWidth - 2.
 149                 let marginTop = previewHeight * (win.scrollViewCurrentImage.VerticalOffset - win.borderCurrentImage.BorderThickness.Top) / canvasHeight - 2.
 150                 let marginBottom = previewHeight * (canvasHeight - (win.scrollViewCurrentImage.VerticalOffset - win.borderCurrentImage.BorderThickness.Bottom) - win.scrollViewCurrentImage.ViewportHeight) / canvasHeight - 2.
 151
 152                 preview.viewport.Margin <-
 153                     Thickness(
 154                         marginLeft,
 155                         marginTop,
 156                         marginRight,
 157                         marginBottom)
 158             else
 159                 preview.viewport.Visibility <- Visibility.Hidden
 160
 161     let rec setAsInfected (srcImg: SourceImage) (rbc: RBC) (infected: bool) =
 162         state.SetAsInfected rbc infected
 163         win.canvasCurrentImage.Children
 164         |> Seq.cast<Views.RBCFrame>
 165         |> Seq.iter
 166             (fun frame ->
 167                 if (frame.Tag :?> RBC) = rbc
 168                 then
 169                     setRBCFrameStyle srcImg rbc frame)
 170         updateRBCFramesPreview ()
 171         updateCurrentImageInformation ()
 172         updateGlobalParasitemia ()
 173
 174     and RBCFrame (srcImg: SourceImage) (rbc: RBC) : Views.RBCFrame =
 175         let frame = RBCFrameFromExisting srcImg rbc (Views.RBCFrame())
 176         frame.SetValue(Panel.ZIndexProperty, Int32.MaxValue - rbc.num) // To be sure the
 177         frame.menuRBCSetAsHealthy.Click.AddHandler(fun obj args -> setAsInfected srcImg (frame.Tag :?> RBC) false)
 178         frame.menuRBCSetAsInfected.Click.AddHandler(fun obj args -> setAsInfected srcImg (frame.Tag :?> RBC) true)
 179         frame.ContextMenuOpening.AddHandler(
 180             fun obj args ->
 181                 if (frame.Tag :?> RBC).infected
 182                 then
 183                     frame.menuRBCSetAsHealthy.Visibility <- Visibility.Visible
 184                     frame.menuRBCSetAsInfected.Visibility <- Visibility.Collapsed
 185                 else
 186                     frame.menuRBCSetAsHealthy.Visibility <- Visibility.Collapsed
 187                     frame.menuRBCSetAsInfected.Visibility <- Visibility.Visible)
 188
 189         frame.ContextMenuClosing.AddHandler(fun obj args -> if not frame.IsMouseOver then highlightRBCFrame frame false )
 190         frame.MouseEnter.AddHandler(fun obj args -> highlightRBCFrame frame true)
 191         frame.MouseLeave.AddHandler(fun obj args -> if not frame.grid.ContextMenu.IsOpen then highlightRBCFrame frame false)
 192         frame
 193
 194     and updateRBCFramesPreview () =
 195         match state.CurrentImage with
 196         | Some srcImg ->
 197             let mutable currentPreview = 0
 198             for rbc in srcImg.rbcs |> List.filter (fun rbc -> displayHealthy || rbc.infected) do
 199                 let previewInfected =
 200                     if currentPreview < win.stackRBC.Children.Count
 201                     then
 202                         RBCFrameFromExisting srcImg rbc (win.stackRBC.Children.[currentPreview] :?> Views.RBCFrame)
 203                     else
 204                         let f = RBCFrame srcImg rbc
 205                         f.MouseLeftButtonUp.AddHandler(fun obj args -> zoomToRBC (f.Tag :?> RBC))
 206                         win.stackRBC.Children.Add(f) |> ignore
 207                         f
 208
 209                 currentPreview <- currentPreview + 1
 210
 211                 previewInfected.Height <- win.stackRBC.ActualHeight
 212                 previewInfected.Width <- win.stackRBC.ActualHeight * rbc.size.Width / rbc.size.Height
 213                 previewInfected.border.Fill <- ImageBrush(BitmapSourceConvert.ToBitmapSource(extractRBCPreview srcImg.img rbc))
 214
 215             win.stackRBC.Children.RemoveRange(currentPreview, win.stackRBC.Children.Count - currentPreview)
 216         | _ -> ()
 217
 218         updateViewportPreview ()
 219
 220     let updateRBCFramesCurrent () =
 221         match state.CurrentImage with
 222         | Some srcImg ->
 223             let mutable currentCanvas = 0
 224             for rbc in srcImg.rbcs do
 225                 let frame =
 226                     if currentCanvas < win.canvasCurrentImage.Children.Count
 227                     then
 228                         RBCFrameFromExisting srcImg rbc (win.canvasCurrentImage.Children.[currentCanvas] :?> Views.RBCFrame)
 229                     else
 230                         let f = RBCFrame srcImg rbc
 231                         f.Root.Opacity <- 0.7
 232                         win.canvasCurrentImage.Children.Add(f) |> ignore
 233                         f
 234
 235                 currentCanvas <- currentCanvas + 1
 236
 237                 Canvas.SetLeft(frame, rbc.center.X - rbc.size.Width / 2.)
 238                 Canvas.SetTop(frame, rbc.center.Y - rbc.size.Height / 2.)
 239
 240             for i in currentCanvas .. win.canvasCurrentImage.Children.Count - 1 do
 241                 win.canvasCurrentImage.Children.[i].Visibility <- Visibility.Hidden
 242         | _ -> ()
 243
 244     let askDocumentPathToSave () : string option =
 245         let dialog = SaveFileDialog(AddExtension = true, DefaultExt = PiaZ.extension, Filter = PiaZ.filter)
 246
 247         if state.FilePath <> ""
 248         then
 249             dialog.FileName <- FileInfo(state.FilePath).Name
 250         elif state.PatientID <> ""
 251         then
 252             dialog.FileName <- state.PatientID + PiaZ.extension
 253
 254         let res = dialog.ShowDialog()
 255         if res.HasValue && res.Value then
 256             Some dialog.FileName
 257         else
 258             None
 259
 260     let saveCurrentDocument () =
 261         try
 262             if state.FilePath = ""
 263             then
 264                 match askDocumentPathToSave () with
 265                 | Some filepath ->
 266                     state.FilePath <- filepath
 267                     state.Save()
 268                 | _ -> ()
 269             else
 270                 state.Save()
 271             updateDocumentStatus ()
 272             displayStatusMessage "Document saved"
 273         with
 274         | :? IOException as ex ->
 275             Log.Error(ex.ToString())
 276             MessageBox.Show(sprintf "The document cannot be save in '%s'" state.FilePath, "Error saving the document", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 277
 278     let saveCurrentDocumentAsNewFile () =
 279         match askDocumentPathToSave () with
 280         | Some filepath ->
 281             state.FilePath <- filepath
 282             saveCurrentDocument ()
 283         | _ -> ()
 284
 285     // Ask the use to save the current document if neccessary.
 286     let askSaveCurrent () =
 287         if state.AlteredSinceLastSave
 288         then
 289             match MessageBox.Show("Would you like to save the current document?", "Saving the current document", MessageBoxButton.YesNo, MessageBoxImage.Question) with
 290             | MessageBoxResult.Yes -> saveCurrentDocument ()
 291             | _ -> ()
 292
 293     let updateCurrentImage () =
 294         match state.CurrentImage with
 295         | Some srcImg ->
 296             win.imgLogos.Visibility <- Visibility.Collapsed
 297
 298             // Highlight the preview.
 299             win.stackPreviews.Children
 300             |> Seq.cast<Views.ImageSourcePreview>
 301             |> Seq.iter (fun preview -> preview.border.BorderThickness <- Thickness(if preview.Tag = (srcImg :> Object) then 3. else 0.))
 302
 303             win.canvasCurrentImage.Height <- float srcImg.img.Height
 304             win.canvasCurrentImage.Width <- float srcImg.img.Width
 305             win.canvasCurrentImage.Background <- ImageBrush(BitmapSourceConvert.ToBitmapSource(srcImg.img))
 306
 307             updateRBCFramesCurrent ()
 308             updateRBCFramesPreview ()
 309
 310         | None ->
 311             win.imgLogos.Visibility <- Visibility.Visible
 312
 313             win.stackRBC.Children.Clear()
 314             win.canvasCurrentImage.Children.Clear()
 315             win.canvasCurrentImage.Background <- canvasCurrentImageColor
 316
 317         updateCurrentImageInformation ()
 318
 319     let setCurrentImage (srcImg: SourceImage) =
 320         if state.CurrentImage.IsNone || state.CurrentImage.Value <> srcImg
 321         then
 322             state.CurrentImage <- Some srcImg
 323             updateCurrentImage ()
 324
 325     let addPreview (srcImg: SourceImage) =
 326         let imgCtrl = Views.ImageSourcePreview(Margin = Thickness(3.))
 327
 328         imgCtrl.menuRemoveImage.Click.AddHandler(fun obj args ->
 329             win.stackPreviews.Children.Remove(imgCtrl)
 330             let srcImg = imgCtrl.Tag :?> SourceImage
 331             let currentRemoved = Some srcImg = state.CurrentImage
 332             state.RemoveSourceImage srcImg
 333             if currentRemoved
 334             then
 335                 updateCurrentImage()
 336
 337             updateGlobalParasitemia()
 338
 339             // Update image numbers.
 340             win.stackPreviews.Children |> Seq.cast<Views.ImageSourcePreview> |> Seq.iter (fun imgPreview -> imgPreview.txtImageNumber.Text <- (imgPreview.Tag :?> SourceImage).num.ToString()))
 341
 342         imgCtrl.Tag <- srcImg
 343         imgCtrl.txtImageNumber.Text <- srcImg.num.ToString()
 344         let width = 200
 345         let height = srcImg.img.Height * width / srcImg.img.Width
 346         imgCtrl.imagePreview.Source <- BitmapSourceConvert.ToBitmapSource(srcImg.img.Resize(width, height, Emgu.CV.CvEnum.Inter.Cubic))
 347         win.stackPreviews.Children.Add(imgCtrl) |> ignore
 348
 349         // Zoom to a mouse position into the control 'imgCtrl'.
 350         let zoomTo (mousePos: Point) =
 351             let canvasW = win.canvasCurrentImage.ActualWidth * currentScale
 352             let canvasH = win.canvasCurrentImage.ActualHeight * currentScale
 353             let centerX = (mousePos.X - imgCtrl.BorderThickness.Left) / (imgCtrl.ActualWidth - imgCtrl.BorderThickness.Left) * canvasW
 354             let centerY = (mousePos.Y - imgCtrl.BorderThickness.Top) / (imgCtrl.ActualHeight - imgCtrl.BorderThickness.Top) * canvasH
 355             win.scrollViewCurrentImage.ScrollToHorizontalOffset(centerX - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
 356             win.scrollViewCurrentImage.ScrollToVerticalOffset(centerY - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
 357
 358         imgCtrl.MouseLeftButtonDown.AddHandler(fun obj args ->
 359             setCurrentImage (state.SourceImages |> Seq.find (fun srcImg -> (srcImg :> Object) = imgCtrl.Tag))
 360             imgCtrl.UpdateLayout()
 361             zoomTo (args.GetPosition(imgCtrl))
 362             imgCtrl.CaptureMouse() |> ignore)
 363
 364         imgCtrl.MouseMove.AddHandler(fun obj args ->
 365             if imgCtrl.IsMouseCaptured
 366             then
 367                 zoomTo (args.GetPosition(imgCtrl)))
 368
 369         imgCtrl.MouseLeftButtonUp.AddHandler(fun obj args ->
 370             if imgCtrl.IsMouseCaptured
 371             then
 372                 imgCtrl.ReleaseMouseCapture())
 373
 374     let updatePreviews () =
 375         win.stackPreviews.Children.Clear ()
 376         for srcImg in state.SourceImages do
 377             addPreview srcImg
 378         updateCurrentImage ()
 379
 380     let updateGUI () =
 381         win.txtPatient.Text <- state.PatientID
 382         updatePreviews ()
 383         updateGlobalParasitemia ()
 384         updateDocumentStatus ()
 385
 386     let loadFile (filepath: string) =
 387         askSaveCurrent ()
 388         let previousFilePath = state.FilePath
 389         try
 390             state.FilePath <- filepath
 391             state.Load()
 392             updateGUI ()
 393         with
 394         | :? IOException as ex ->
 395             Log.Error(ex.ToString())
 396             state.FilePath <- previousFilePath
 397             MessageBox.Show(sprintf "The document cannot be loaded from '%s'" state.FilePath, "Error loading the document", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 398
 399     let askLoadFile () =
 400         let dialog = OpenFileDialog(Filter = PiaZ.filter)
 401         let res = dialog.ShowDialog()
 402         if res.HasValue && res.Value
 403         then loadFile dialog.FileName
 404
 405     let newFile () =
 406         askSaveCurrent ()
 407         state.Reset()
 408         updateGUI()
 409
 410     let exportResults () =
 411         let extension = ".txt"
 412         let dialog = SaveFileDialog(AddExtension = true, DefaultExt = extension)
 413
 414         if state.FilePath <> ""
 415         then
 416             dialog.FileName <- Path.GetFileNameWithoutExtension(state.FilePath) + extension
 417         elif state.PatientID <> ""
 418         then
 419             dialog.FileName <- state.PatientID + extension
 420
 421         let res = dialog.ShowDialog()
 422         if res.HasValue && res.Value then
 423             try
 424                 Export.exportResults state dialog.FileName
 425             with
 426             | :? IOException as ex ->
 427                 Log.Error(ex.ToString())
 428                 MessageBox.Show(sprintf "The results cannot be exported in '%s'" state.FilePath, "Error exporting the files", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 429
 430     win.txtPatient.TextChanged.AddHandler(fun obj args -> state.PatientID <- win.txtPatient.Text)
 431
 432     win.menuExit.Click.AddHandler(fun obj args -> win.Root.Close())
 433     win.menuSave.Click.AddHandler(fun obj args -> saveCurrentDocument ())
 434     win.menuSaveAs.Click.AddHandler(fun obj args -> saveCurrentDocumentAsNewFile ())
 435     win.menuOpen.Click.AddHandler(fun obj args -> askLoadFile ())
 436     win.menuNew.Click.AddHandler(fun obj args -> newFile ())
 437     win.menuExportResults.Click.AddHandler(fun obj args -> exportResults ())
 438
 439     win.menuAddSourceImage.Click.AddHandler(fun obj args ->
 440         let dialog = OpenFileDialog(Filter = "Image Files|*.png;*.jpg;*.tif;*.tiff", Multiselect = true)
 441         let res = dialog.ShowDialog()
 442         if res.HasValue && res.Value
 443         then
 444             let noSourceImage = state.SourceImages.Count() = 0
 445
 446             for filename in dialog.FileNames do
 447                 try
 448                     let srcImg = state.AddSourceImage filename defaultConfig
 449                     addPreview srcImg
 450                 with
 451                 | _ as ex ->
 452                     Log.Error(ex.ToString())
 453                     MessageBox.Show(sprintf "Unable to read the image from '%s'" filename, "Error adding an image", MessageBoxButton.OK, MessageBoxImage.Error) |> ignore
 454
 455             updateGlobalParasitemia ()
 456
 457             if noSourceImage
 458             then
 459                 updateCurrentImage ())
 460
 461     win.menuAnalysis.SubmenuOpened.AddHandler(fun obj args -> win.menuStartAnalysis.IsEnabled <- state.SourceImages.Count() > 0)
 462
 463     win.menuStartAnalysis.Click.AddHandler(fun obj args ->
 464         if Analysis.showWindow win.Root state
 465         then
 466             updateGlobalParasitemia ()
 467             updateCurrentImage ())
 468
 469     win.menuHightlightRBC.Click.AddHandler(fun obj args ->
 470         displayHealthy <- win.menuHightlightRBC.IsChecked
 471         updateRBCFramesPreview ()
 472         updateRBCFramesCurrent ())
 473
 474     win.menuAbout.Click.AddHandler(fun obj args -> About.showWindow win.Root)
 475
 476     win.Root.Closing.AddHandler(fun obj args -> askSaveCurrent ())
 477
 478     // Zoom on the current image.
 479     let adjustCurrentImageBorders (deltaX: float) (deltaY: float) =
 480         win.borderCurrentImage.BorderThickness <-
 481             Thickness(
 482                 (win.scrollViewCurrentImage.ViewportWidth + deltaX) / 2.,
 483                 (win.scrollViewCurrentImage.ViewportHeight + deltaY) / 2.,
 484                 (win.scrollViewCurrentImage.ViewportWidth + deltaX) / 2.,
 485                 (win.scrollViewCurrentImage.ViewportHeight + deltaY) / 2.)
 486
 487     win.canvasCurrentImage.SizeChanged.AddHandler(fun obj args ->
 488         let deltaX = args.NewSize.Width - args.PreviousSize.Width
 489         let deltaY = args.NewSize.Height - args.PreviousSize.Height
 490         if deltaX > 0.5 || deltaY > 0.5
 491         then
 492             adjustCurrentImageBorders 0.0 0.0
 493             // Center the view at the center of the image initialy.
 494             win.scrollViewCurrentImage.UpdateLayout()
 495             win.scrollViewCurrentImage.ScrollToHorizontalOffset(win.borderCurrentImage.ActualWidth / 2. - win.scrollViewCurrentImage.ViewportWidth / 2.)
 496             win.scrollViewCurrentImage.ScrollToVerticalOffset(win.borderCurrentImage.ActualHeight / 2. - win.scrollViewCurrentImage.ViewportHeight / 2.))
 497
 498     win.scrollViewCurrentImage.SizeChanged.AddHandler(fun obj args ->
 499         let deltaX = args.NewSize.Width - args.PreviousSize.Width
 500         let deltaY = args.NewSize.Height - args.PreviousSize.Height
 501         adjustCurrentImageBorders deltaX deltaY
 502         win.scrollViewCurrentImage.ScrollToHorizontalOffset(win.scrollViewCurrentImage.HorizontalOffset + deltaX / 8.)
 503         win.scrollViewCurrentImage.ScrollToVerticalOffset(win.scrollViewCurrentImage.VerticalOffset + deltaY / 8.))
 504
 505     let mutable maxScale = 4.
 506     let mutable minScale = 0.25
 507     let currentImageScaleTransform = ScaleTransform()
 508     win.canvasCurrentImage.LayoutTransform <- currentImageScaleTransform
 509     win.borderCurrentImage.PreviewMouseWheel.AddHandler(fun obj args ->
 510         let scaleFactor = if args.Delta > 0 then 2.0 else 0.5
 511         if scaleFactor > 1. && currentScale < maxScale || scaleFactor < 1. && currentScale > minScale
 512         then
 513             let previousScale = currentScale
 514             currentScale <-
 515                 let newScale = currentScale * scaleFactor
 516                 if newScale > maxScale then maxScale elif newScale < minScale then minScale else newScale
 517             let realScaleFactor = currentScale / previousScale
 518
 519             let centerX = win.scrollViewCurrentImage.HorizontalOffset + win.scrollViewCurrentImage.ViewportWidth / 2. - win.borderCurrentImage.BorderThickness.Left
 520             let centerY = win.scrollViewCurrentImage.VerticalOffset + win.scrollViewCurrentImage.ViewportHeight / 2. - win.borderCurrentImage.BorderThickness.Top
 521
 522             currentImageScaleTransform.ScaleX <- currentScale
 523             currentImageScaleTransform.ScaleY <- currentScale
 524
 525             win.scrollViewCurrentImage.ScrollToHorizontalOffset(centerX * realScaleFactor - win.scrollViewCurrentImage.ViewportWidth / 2. + win.borderCurrentImage.BorderThickness.Left)
 526             win.scrollViewCurrentImage.ScrollToVerticalOffset(centerY * realScaleFactor - win.scrollViewCurrentImage.ViewportHeight / 2. + win.borderCurrentImage.BorderThickness.Top)
 527
 528         args.Handled <- true)
 529
 530     // Pan on the current image.
 531     let mutable scrollStartPosition = Point(0., 0.)
 532     let mutable scrollStartOffsetX = 0.
 533     let mutable scrollStartOffsetY = 0.
 534     win.borderCurrentImage.PreviewMouseLeftButtonDown.AddHandler(fun obj args ->
 535         scrollStartPosition <- args.GetPosition(win.scrollViewCurrentImage)
 536         scrollStartOffsetX <- win.scrollViewCurrentImage.HorizontalOffset
 537         scrollStartOffsetY <- win.scrollViewCurrentImage.VerticalOffset
 538         win.borderCurrentImage.Cursor <- Input.Cursors.ScrollAll
 539         win.borderCurrentImage.CaptureMouse() |> ignore
 540         args.Handled <- true)
 541
 542     win.borderCurrentImage.PreviewMouseMove.AddHandler(fun obj args ->
 543         if win.borderCurrentImage.IsMouseCaptured
 544         then
 545             let position = args.GetPosition(win.scrollViewCurrentImage)
 546             let deltaX = scrollStartPosition.X - position.X
 547             let deltaY = scrollStartPosition.Y - position.Y
 548             win.scrollViewCurrentImage.ScrollToHorizontalOffset(deltaX + scrollStartOffsetX)
 549             win.scrollViewCurrentImage.ScrollToVerticalOffset(deltaY + scrollStartOffsetY)
 550
 551             args.Handled <- true)
 552
 553     win.borderCurrentImage.PreviewMouseLeftButtonUp.AddHandler(fun obj args ->
 554         if win.borderCurrentImage.IsMouseCaptured
 555         then
 556             win.borderCurrentImage.Cursor <- Input.Cursors.Arrow
 557             win.borderCurrentImage.ReleaseMouseCapture()
 558             args.Handled <- true)
 559
 560     // Shortcuts.
 561     // Save.
 562     win.Root.InputBindings.Add(
 563         Input.KeyBinding(
 564             FSharp.ViewModule.FunCommand((fun obj -> saveCurrentDocument ()), (fun obj -> true)),
 565             Input.KeyGesture(Input.Key.S, Input.ModifierKeys.Control))) |> ignore
 566
 567     // Save as.
 568     win.Root.InputBindings.Add(
 569         Input.KeyBinding(
 570             FSharp.ViewModule.FunCommand((fun obj -> saveCurrentDocumentAsNewFile ()), (fun obj -> true)),
 571             Input.KeyGesture(Input.Key.S, Input.ModifierKeys.Control ||| Input.ModifierKeys.Shift))) |> ignore
 572
 573     // Open.
 574     win.Root.InputBindings.Add(
 575         Input.KeyBinding(
 576             FSharp.ViewModule.FunCommand((fun obj -> askLoadFile ()), (fun obj -> true)),
 577             Input.KeyGesture(Input.Key.O, Input.ModifierKeys.Control))) |> ignore
 578
 579     // New file.
 580     win.Root.InputBindings.Add(
 581         Input.KeyBinding(
 582             FSharp.ViewModule.FunCommand((fun obj -> newFile ()), (fun obj -> true)),
 583             Input.KeyGesture(Input.Key.N, Input.ModifierKeys.Control))) |> ignore
 584
 585     // Export results.
 586     win.Root.InputBindings.Add(
 587         Input.KeyBinding(
 588             FSharp.ViewModule.FunCommand((fun obj -> exportResults ()), (fun obj -> true)),
 589             Input.KeyGesture(Input.Key.E, Input.ModifierKeys.Control))) |> ignore
 590
 591     // Viewport preview.
 592     win.scrollViewCurrentImage.ScrollChanged.AddHandler(fun obj args -> updateViewportPreview ())
 593
 594     updateDocumentStatus ()
 595     win.gridImageInformation.Visibility <- Visibility.Hidden
 596
 597     win.Root.Show()
 598
 599     match fileToOpen with
 600     | Some filepath -> loadFile filepath
 601     | None -> ()
 602
 603     app.Run()